Antibacterial and Antioxidant Activity Evaluation of Bis-Substituted ?sovanillin Derivatives
نویسندگان
چکیده
Herein, a series of twelve bis-hydrazone substituted isovanilline derivatives 3(a-l), were freshly re-synthesized by the reaction bis-aldehydes with hydrazide since these compounds previously showed potent aldose reductase inhibition properties. The obtained tested for their potential antibacterial and antioxidant activities. In present study, four different bacterial strains used, including Gram-positive (Staphylococcus aureus ATCC 29213, Enterococcus faecalis 29212) Gram-negative (Pseudomonas aeruginosa 10231, Escherichia coli 25912). On other hand, capacities determined using several methods, DPPH free radical scanvenging, TEAC cupric reducing (CUPRAC) metal chelating activity methods. Several lead molecules discovered as inhibitors against S. E. strains. More specifically, 3g (R=-H) 3j (R= -4Cl) great properties having MIC values 1.56 6.25 µg/mL, respectively. Moreover, none methods respect to compared standards.
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ژورنال
عنوان ژورنال: Journal of the Turkish Chemical Society, Section A: Chemistry
سال: 2023
ISSN: ['2149-0120']
DOI: https://doi.org/10.18596/jotcsa.1196335